Tetrahedron letters

A one pot synthesis of α-(alkoxysilyl) acetic esters

O Andrey, Y Landais, D Planchenault

文献索引：Andrey, Olivier; Landais, Yannick; Planchenault, Denis Tetrahedron Letters, 1993 , vol. 34, # 18 p. 2927 - 2930

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被引用次数: 31

摘要

Abstract An efficient synthesis of α-(alkoxysilyl) acetic esters by Si H insertion of carbenes, generated by rhodium catalysed decomposition of diazoacetic esters, followed by nucleophilic displacement of Cl by ROH has been developed. Alkylation of these α-silyl carbonyls followed by Tamao oxidation of the C Si bond allow an easy access to terminal diols.