Hypolipicllemic Activity of Cyclic lmido Alkyl Ethers, Thioethers, Sulfoxides, and Sulfones

JM Chapman, WJ Sowell, G Abdalla, IH Hall…

文献索引：Chapman Jr.; Sowell Sr.; Abdalla; Hall; Wong Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 11 p. 903 - 909

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被引用次数: 14

摘要

Abstract N-Substituted alkyl others, thioethers, sulfoxides, and sulfones of cyclic imides (eg, phthalimide, saccharin, 1, 8-naphthalimide, succinimide, and 2, 3-dihydrophthalazine-1, 4- dione) were shown to have potent hypolipidemic activity at doses of 10 and 20 mg/kg/d in rodents. These N-substitutions afforded no improvement over other known N-substitutions (eg, butyl, 3-butanone, or the propionic acid derivatives of phthalimide, saccharin, and 2, 3 ...