Tetrahedron letters

Facile synthesis of thiazoles via an intramolecular thia-Michael strategy

PK Sasmal, S Sridhar, J Iqbal

文献索引：Sasmal, Pradip K.; Sridhar; Iqbal, Javed Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8661 - 8665

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被引用次数: 22

摘要

A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introduce various oxo and thio functionalities including aliphatic and aromatic moieties, especially at the C2-position of thiazoles.