Tetrahedron

Peptides—XI: Synthesis of peptides derived from alpha-methylalanine

MT Leplawy, DS Jones, GW Kenner, RC Sheppard

文献索引：Leplawy,M.T. et al. Tetrahedron, 1960 , vol. 11, p. 39 - 51

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被引用次数: 142

摘要

Union of α-methylalanyl residues in a peptide chain is severely sterically hindered. This hindrance can be overcome by employing either the mixed anhydride (I) of pivalic acid and benzyloxycarbonyl-α-methylalanine or, more generally, oxazolones (II), including 4, 4- dimethyl-2-trifluoromethyloxazolone (II; R= CF3). 4, 4-Dimethyloxazolone (II; R= H) has been obtained in solution and characterized by its infra-red spectrum; it is attacked by α- ...