Studies of the mode of action of antitumor triazenes and triazines. 6. 1-Aryl-3-(hydroxymethyl)-3-methyltriazenes: synthesis, chemistry, and antitumor properties

K Vaughan, Y Tang, G Llanos, JK Horton…

文献索引：Vaughan; Tang; Llanos; Horton; Simmonds; Hickman; Stevens Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 357 - 363

全文：HTML全文

被引用次数: 30

摘要

Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, B3H 3C3, Canada, and Department of Pharmacy, University of Aston, Gosta Green, Birmingham B4 7ET, England. Received June 29, 1983 l-Aryl-3-(hydroxymethyl)-3-alkyltriazenes [ArN= NN (CH3) CH20H] have been synthesized by diazonium coupling to the carbinolamine (RNHCHzOH), generated in situ from the alkylamine and formaldehyde mixtures. The (hydroxymethy1) ...