Tetrahedron

Regioselective synthesis of 1-allyl-and 1-arylmethyl uracil and thymine derivatives

V Malik, P Singh, S Kumar

文献索引：Malik, Vaishali; Singh, Palwinder; Kumar, Subodh Tetrahedron, 2005 , vol. 61, # 16 p. 4009 - 4014

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被引用次数: 24

摘要

2, 4-Bis (trimethylsiloxy) pyrimidines with allyl halides and arylmethyl halides in 1, 2- dichloroethane in the presence of I2 regioselectively provide 1-allyl-/1-arylmethyl-uracil and thymine derivatives. The secondary aryl alkyl and diaryl methyl halides with provide chiral 1- arylalkyl/1-(diarylmethyl) uracil/thymine derivatives. The procedure has been extended to the synthesis of fluorescent uracil/thymine derivatives.