Biosynthesis of the antitumor antibiotic sparsomycin

RJ Parry, Y Li, EE Gomez

文献索引：Parry; Li; Gomez Journal of the American Chemical Society, 1992 , vol. 114, # 15 p. 5946 - 5959

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被引用次数: 29

摘要

Abstract: The biosynthesis of the antitumor antibiotic sparsomycin (1) has been investigated by administration of isotopically labeled precursors to Streptomyces sparsogenes var. sparsogenes. These studies indicated that the dithioacetal moiety (2) of sparsomycin is derived from L-cysteine via the intermediacy of S-methylcysteine and S-(methylthiomethyl) cysteine, with reduction of the carboxyl group of S-(methylthiomethy1) cysteine preceding ...