Tetrahedron letters

Lipase-catalysed selective monoacylation of 1, n-diols with vinyl acetate

V Framis, F Camps, P Clapés

文献索引：Framis, Victoria; Camps, Francisco; Clapes, Pere Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5031 - 5033

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被引用次数: 19

摘要

A simple enzymatic methodology for the selective monoacetylation of 1, n-diols (n= 5, 8) using vinyl acetate is reported. Monoacetylation excesses of 81–87% at 74–90% 1, n-diol conversions were obtained in toluene and diisopropyl ether using Thermomyces lanuginosus lipase (TLL) immobilised on polypropylene powder as catalyst.