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Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors

CA Lipinski, CE Aldinger, TA Beyer…

文献索引：Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177

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被引用次数: 29

摘要

Previous studies from these laboratories have described the excellent in vitro and in vivo activity of spirohydantoin aldose reductase inhibitors (ARIs).'Clinical trials with the spirohydantoin sorbinil suggested efficacy" but were terminated because of a low incidence of side effects similar to those of the hydantoin anticonvulsant dilantix~.~ Because both drugs are hydantoins and have qualitatively similar side effects, we decided either to ...

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