Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal β-N-acetylhexosaminidase
…, E Vavříková, K Slámová, H Pelantová, S Riva…
文献索引：Krejzova, Jana; Simon, Petr; Vavrikova, Eva; Slamova, Kristyna; Pelantova, Helena; Riva, Sergio; Spiwok, Vojtech; Kren, Vladimir Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 87, p. 128 - 134
β-N-Acetylhexosaminidases (EC 3.2. 1.52) from the CAZy glycoside hydrolase families 20 and 84 are two distinct enzyme groups with similar reactivity and different physiological functions, thus selective inhibition of these enzymes is of crucial importance. Here, we report on the lipase-catalyzed synthesis of a set of novel monomeric and dimeric C-6-acylated derivatives of NAG-thiazoline, which is a typical competitive inhibitor of both these enzyme ...
