Synthesis

Synthesis of 4-Alkyl-and 4-(ω-Chloroalkyl)-3-hydroxy-5-alkylidenebutenolides Based On Cyclizations of 4-Alkyl-and 4-(ω-Chloroalkyl)-1, 3-bis (trimethylsilyloxy) buta- …

E Bellur, B Appel, P Langer

文献索引：Nguyen, Van Thi Hong; Bellur, Esen; Appel, Bettina; Langer, Peter Synthesis, 2006 , # 17 p. 2865 - 2872

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被引用次数: 29

摘要

A number of naturally occurring butenolides, such as multicolic and multicolosic acid (Figure [1] ) isolated from Penicillium multicolor, contain a functionalized or non-functionalized alkyl chain at C-3. [5] However, the application of our dianion methodology [3a] to the synthesis of products containing an alkyl chain located at C-4 of the butenolide moiety, that is, at a different location, proved to be unsuccessful. For example, the reaction of dilithiated ethyl 3- ...