Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6, 8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3 (4H)-yl) …

G Saravanan, V Alagarsamy, CR Prakash

文献索引：Saravanan, Govindaraj; Alagarsamy, Veerachamy; Prakash, Chinnasamy Rajaram Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3072 - 3078

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被引用次数: 19

摘要

Novel quinazolinone derivatives 5a–5n were designed, synthesized and screened for antiepileptic activity using MES and scPTZ seizures tests. Neurotoxicity study was performed by rotorod test. Compounds 5c, 5d, 5g, 5j and 5k were found active in the preliminary screening in MES model and/or scPTZ model. Further all these five compounds were administered to rats, 5c and 5d showed better activity than Phenytoin in oral route. Among ...