Aminocyclopropanes as precursors of endoperoxides with antimalarial activity

…, B Crousse, I Florent, P Grellier, P Retailleau…

文献索引：Madelaine, Claire; Buriez, Olivier; Crousse, Benoit; Florent, Isabelle; Grellier, Philippe; Retailleau, Pascal; Six, Yvan Organic and Biomolecular Chemistry, 2010 , vol. 8, # 24 p. 5591 - 5601

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被引用次数: 6

摘要

This contribution describes the synthesis of several novel bicyclic α-amino endoperoxides, including CF3-substituted compounds, prepared by the aerobic electrochemical oxidation of a family of bicyclic aminocyclopropanes. These, in turn, are readily synthesised by a titanium- mediated intramolecular cyclopropanation process (Kulinkovich–de Meijere reaction), starting from N-alkenyl amides that contain a vic-disubstituted double bond, with high ...