Synthesis, antitumor evaluation, molecular modeling and quantitative structure–activity relationship (QSAR) of some novel arylazopyrazolodiazine and triazine …

A El-Shafei, AA Fadda, AM Khalil, TAE Ameen…

文献索引：El-Shafei, Ahmed; Fadda; Khalil; Ameen; Badria, Farid A. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5096 - 5105

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被引用次数: 42

摘要

The synthesis, in vivo and in vitro antitumor evaluation, and QSAR studies of some novel pyrazole analogs against Ehrlich Ascites Carcinoma (EAC) cells were described. In vitro results revealed that compounds 10, 6 and 4 were the most potent analogs against EAC, respectively. Moreover, in vivo evaluation of compounds 6 and 10 proved their capability to normalize the blood picture in comparison to 5-FU, a well known anticancer drug. These ...