Tetrahedron letters

The application of vinamidinium salts to the synthesis of 2, 4-disubstituted thiophenes

RT Clemens, SQ Smith

文献索引：Clemens, Ryan T.; Smith, Stanton Q. Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1319 - 1320

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被引用次数: 9

摘要

The synthesis of 2, 4-disubstituted thiophenes by the condensation of symmetrical vinamidinium salts with methyl thioglycolate has been accomplished for the first time. Simple experimental conditions were used to prepare seven different methyl 4-aryl-2- thiophenecarboxylates, three of which are new compounds.