Syntheses of some hydroxylated metabolites of psychotropic trifluoromethyl analogs of chlorpromazine

EA Nodiff, HL Sharma, PC Taunk…

文献索引：Nodiff; Sharma; Taunk; et al. Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 8 p. 1529 - 1532

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被引用次数: 9

摘要

The syntheses of 7-hydroxy derivatives of trifluoperazine, nor,-trifluoperazine, fluphenazine, trifluprorn- azine and nor,-trifluprornazine are described. These were prepared as analytical standards for the identifica- tion of these metabolites in biological materials. ... In order to design more effective psychotropic agents it is important to fully understand their mode of action. Es- sential to this understanding, is the knowledge of their metabolites whose identification ...