Antimalarial activity of 2-(substituted amino)-4, 6-bis (trichloromethyl)-1, 3, 5-triazines and N-(chlorophenyl)-N'-[4-(substituted amino)-6-(trichloromethyl)-1, 3, 5-triazin- …

LM Werbel, EF Elslager, C Hess…

文献索引：Werbel, Leslie M.; Elslager, Edward F.; Hess, Carolyn; Hutt, Marland P. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1943 - 1948

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被引用次数: 29

摘要

Generally, structural requirements for potent antimalarial activity in the chlorguanide (V), cycloguanil (VI), and pyrimethamine series (VII) are rather specific and parallel to each other. Furthermore, strains of malarial parasites resistant to one of these drugs are usually cross-resistant to the other two substances.