Helvetica chimica acta

An Unexpected Formation of a 14??Membered Cyclodepsipeptide

B Iliev, A Linden, H Heimgartner

文献索引：Iliev, Boyan; Linden, Anthony; Heimgartner, Heinz Helvetica Chimica Acta, 2003 , vol. 86, # 9 p. 3215 - 3234

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被引用次数: 16

摘要

Abstract The treatment of diluted solutions of the hydroxy diamides 6a and 6b in toluene with HCl gas at 100 gave the dimeric, 14-membered cyclodepsipeptide 10 in up to 72% yield (Scheme 3). The same product was formed from the linear dimer of 6b, the depsipeptide 11, under the same conditions (cf. Scheme 4). All attempts to prepare the cyclic seven- membered monomer 9, starting with different precursors and using different lactonization ...