Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted) phenylpyrimidines as anti-cancer agents

…, S Ayral-Kaloustian, T Nguyen, R Hernandez…

文献索引：Zhang, Nan; Ayral-Kaloustian, Semiramis; Nguyen, Thai; Hernandez, Richard; Lucas, Judy; Discafani, Carolyn; Beyer, Carl Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 111 - 118

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被引用次数: 20

摘要

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5- (substituted) phenylpyrimidines as anti-cancer agents are described. This series of 2- heteroarylpyrimidines was developed by modifying a series of anti-tumor [1, 2, 4] triazolo [1, 5-a] pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ...