Abstract: The syntheses of 8-cyano-3-R-IO-methyl-5-deazaisoalloxazines (111) are described as is a comparison of the reactions of 111 and 3-R-10-methyl-5- deazaisoalloxazine (I) with a number of nucleophiles. Thiol anions, S032-, HS03-, CN-, HO-, and HOz-add to the 5 position of 111. Though RS-species provide no detectable reaction with 1, the pseudo-first-order rate constants for addition to 111 exceed 170 sl. The ...
