Tetrahedron

Synthesis of new acyclonucleosides comprising unexpected regioisomers in the case of purines

S Guillarme, S Legoupy, N Bourgougnon, AM Aubertin…

文献索引：Guillarme, Stephane; Legoupy, Stephanie; Bourgougnon, Nathalie; Aubertin, Anne-Marie; Huet, Francois Tetrahedron, 2003 , vol. 59, # 48 p. 9635 - 9639

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被引用次数: 14

摘要

Nucleoside analogues are currently used as antiviral agents, for instance against human immunodeficiency virus (HIV), or hepatitis B (HBV) and herpes viruses. In several cases, acyclic nucleosides appeared as an useful class of compounds for antiviral chemotherapy. 1 Indeed, the remarkable activity of acyclonucleosides such as acyclovir 1 2 and ganciclovir 2 3 which are potent antiherpetic agents shows the interest of this class of compounds. In these cases, the biological ...