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Synthesis

One-pot synthesis of 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water

F Fringuelli, O Piermatti, F Pizzo

文献索引:Fringuelli, Francesco; Piermatti, Oriana; Pizzo, Ferdinando Synthesis, 2003 , # 15 p. 2331 - 2334

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被引用次数: 48

摘要

Abstract Chloro-, hydroxy-, methoxy-, and tert-butyl-substituted 3-carboxycoumarins have been prepared by one-pot procedure by reaction of suitably substituted salicylaldehydes with malononitrile in water. The over-all yields are high and the protocol does not require organic solvents.