Bioorganic & medicinal chemistry

The triphosphate of β-d-4′-C-ethynyl-2′, 3′-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase

MA Siddiqui, VE Marquez

文献索引：Siddiqui, Maqbool A.; Marquez, Victor E. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 283 - 287

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被引用次数: 3

摘要

The enantioselective synthesis of the β-d (1) enantiomer of 4′-C-ethynyl-2′, 3′- dideoxycytidine confirms an earlier stereochemical assignment that was strictly based on the ability of HIV reverse transcriptase and its M184V mutant to discriminate between the d- ...