Enantioselective α-and γ-Alkylation of α, β-Unsaturated Aldehydes Using Dienamine Activation

…, R Fröhlich, C Strohmann, M Christmann

文献索引：Stiller, Julian; Marques-Lopez, Eugenia; Herrera, Raquel P.; Froehlich, Roland; Strohmann, Carsten; Christmann, Mathias Organic Letters, 2011 , vol. 13, # 1 p. 70 - 73

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被引用次数: 65

摘要

The enantioselective alkylation of α, β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ-alkylation of linear α, β-unsubstituted enals.