Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

B Li, B Zhou, H Lu, L Ma, AY Peng

文献索引：Li, Baojian; Zhou, Binhua; Lu, Hailiang; Ma, Lin; Peng, Ai-Yun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1955 - 1963

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被引用次数: 24

摘要

Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the present study, we prepared forty-five isocoumarin phosphorus analogues (ie, phosphaisocoumarins) and investigated the inhibition of these compounds on the CEase. The results showed that ...