Methoxylation of desazadesferrithiocin analogues: enhanced iron clearing efficiency

RJ Bergeron, J Wiegand, JS McManis…

文献索引：Karmarkar, Sanjay N.; Kelkar, Shriniwas L.; Wadia, Murzban S. Synthesis, 1985 , # 5 p. 510 - 512

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被引用次数: 37

摘要

... a In the monkeys (n = 4, except for compound 4, n = 7), the dose was 150 μmol/kg ... Design Concept and Synthesis. ... This finding encouraged us to further explore the effect of altering the lipophilicity of the (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-thiazolecarboxylic acids on their ...