2-(Aminomethyl) phenols, a new class of saluretic agents. 1. Effects of nuclear substitution

GE Stokker, AA Deana, SJ Desolms…

文献索引：Stokker; Deana; deSolms; Schultz; Smith; Cragoe Jr.; Baer; Ludden; Russo; Scriabine; Sweet; Watson Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1414 - 1427

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被引用次数: 43

摘要

A series of 2-(aminomethy1) phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or PO administration. The most active compounds belong to a subseries of 4-alkyl-6- halo derivatives of which 2, 2-(aminomethyl)-4-(l, l-dimethylethyl)-6-iodophenol, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive ...