Study of the chemoselectivity of Grignard reagent addition to substrates containing both nitrile and Weinreb amide functionalities

K Harikrishna, A Rakshit…

文献索引：Harikrishna, Kommidi; Rakshit, Ananya; Aidhen, Indrapal Singh European Journal of Organic Chemistry, 2013 , # 22 p. 4918 - 4932

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被引用次数: 5

摘要

Abstract Several substrates containing both cyano and Weinreb amide functionalities have been synthesized to study the chemoselectivity of their reactions with organomagnesium bromides (ArMgBr and RMgBr). Excellent chemoselectivity towards the Weinreb amide was observed in most cases, even in the presence of excess Grignard reagent, affording cyano ketones in good-to-excellent yields.

116332-64-0

N-甲氧基-N-甲基-4-氰基苯甲酰胺

~77%

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