Improved specific Synthesis of [1′??15N]??and [3′??15N] L??histidine

C Soede??Huijbregts, M Van Laren…

文献索引：Soede-Huijbregts; Van Laren; Hulsbergen; Raap; Lugtenburg Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 12 p. 831 - 841

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被引用次数: 7

摘要

Abstract Specifically, 15 N-enriched L-histidines have been prepared. The labelling methodology involves introduction of labels in its precursor 1-benzyl-5-hydroxy methyl imidazole, which is converted into L-histidine via the Schöllkopf method. The procedure allows the preparation of the intermediates and finally histidine with high 15 N enrichment (99%) at each position, in 29% overall yield starting with 15 NH 4 Cl and 56% with KSC 15 ...