Tetrahedron

Synthetic study of tautomycin. Part 2: Synthesis of Ichihara's fragment based on regioselective enzymatic acetylation of complex molecule

…, S Nagumo, T Arai, M Akuzawa, N Kawahara, H Akita

文献索引：Ishii, Yusuke; Nagumo, Shinji; Arai, Takayuki; Akuzawa, Masami; Kawahara, Norio; Akita, Hiroyuki Tetrahedron, 2006 , vol. 62, # 4 p. 716 - 725

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被引用次数: 10

摘要

Formal synthesis of tautomycin, which inhibits type 1 and type 2A protein phosphatases, was achieved. Spiroketal diol was synthesized from alcohol or. The regioselective enzymatic acetylation of with the lipase 'Amano PS'gave monoacetate in 90% yield, which was converted into Ichihara's intermediate based on Julia coupling and Wittig homologation.