In 2005, Davies, Andersen, and co-workers disclosed the uncialamycin 1, a new “enediyne” natural product isolated from an undescribed streptomycete obtained from the surface of a lichen Cladonia uncialis.(1) The first biological evaluations showed that 1 possesses potent in vitro antibacterial activity against Staphylococcus aurens, Escheridia coli, and Burkholderia apia. Despite the small amount of product available (∼300 μg were isolated) the structure of 1 ...
