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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synlett

Total synthesis of pterosines B and C via a photochemical key step

P Wessig, J Teubner

文献索引：Wessig, Pablo; Teubner, Janek Synlett, 2006 , # 10 p. 1543 - 1546

全文：HTML全文

被引用次数: 34

摘要

Abstract A total synthesis of pterosines B and C is reported. Starting with a fourfold substituted benzene derivative, the introduction of the remaining substituents is mainly based on Sonogashira couplings followed by different transformations of the ethyne moiety. The key step is a photochemical ring-closure of an α-mesyloxy ketone forming the 1- indanone skeleton.

未登录结构式

~%

球蛋白B结构式

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球蛋白B结构式

3-ethynyl-2,4,6-trimethylphenethyl acetate结构式

3-ethynyl-2,4,6...

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球蛋白B结构式

2,4,6-trimethyl-3-((trimethylsilyl)ethynyl)phenethyl acetate结构式

2,4,6-trimethyl...

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球蛋白B结构式

2-溴均三甲基苯结构式

2-溴均三甲基苯

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球蛋白B结构式

2,4,6-三甲基苯乙醇结构式

2,4,6-三甲基苯乙醇

~%

球蛋白B结构式

未登录结构式

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球蛋白B结构式

2,4,6-trimethyl-3-(2-((methylsulfonyl)oxy)acetyl)phenethyl acetate结构式

2,4,6-trimethyl...

~%

球蛋白B结构式

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

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球蛋白B结构式

5,7-dimethyl-6-[2'-hydroxyethyl]-indan-1-one结构式

5,7-dimethyl-6-...

碘甲烷结构式

~43%

球蛋白B结构式

2-溴均三甲基苯结构式

2-溴均三甲基苯

~54%

(4-溴-3,5-二甲基苯基)甲醇结构式

(4-溴-3,5-二甲基苯基)甲醇

环氧乙烷结构式

2-溴均三甲基苯结构式

2-溴均三甲基苯

~99%

2,4,6-三甲基苯乙醇结构式

2,4,6-三甲基苯乙醇

未登录结构式

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

未登录结构式

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

3-ethynyl-2,4,6-trimethylphenethyl acetate结构式

3-ethynyl-2,4,6...

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

2,4,6-trimethyl-3-((trimethylsilyl)ethynyl)phenethyl acetate结构式

2,4,6-trimethyl...

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

2-溴均三甲基苯结构式

2-溴均三甲基苯

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

2,4,6-三甲基苯乙醇结构式

2,4,6-三甲基苯乙醇

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

未登录结构式

~%

2-(4,6-dimethyl-3-oxo-1,2-dihydroinden-5-yl)ethyl acetate结构式

2-(4,6-dimethyl...

2,6-二甲基苯酚结构式

2,6-二甲基苯酚

二氧化碳结构式

~34%

4-羟基-3,5-二甲基苯甲酸结构式

4-羟基-3,5-二甲基苯甲酸

Ptaquiloside, a potent carcinogen isolated from bracken fern...

[Ojika, Makoto; Wakamatsu, Kazumasa; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1987 , vol. 43, # 22 p. 5261 - 5274]

Ptaquiloside, a potent carcinogen isolated from bracken fern...

[Ojika, Makoto; Wakamatsu, Kazumasa; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1987 , vol. 43, # 22 p. 5261 - 5274]