Organic letters

Enantioselective Hydrogenation of α-Aryloxy α, β-Unsaturated Acids. Asymmetric Synthesis of α-Aryloxycarboxylic Acids

PE Maligres, SW Krska, GR Humphrey

文献索引：Maligres, Peter E.; Krska, Shane W.; Humphrey, Guy R. Organic Letters, 2004 , vol. 6, # 18 p. 3147 - 3150

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被引用次数: 36

摘要

A facile preparation of chiral α-aryloxy carboxylic acids via asymmetric hydrogenation of the corresponding unsaturated acids has been discovered. A number of catalysts have been identified that give high product enantioselectivity, and the scope of the reaction has been examined with respect to substitution on the aromatic ring and olefin.