Total Synthesis of 16??Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues

…, A Bigot, B Werschkun, N Winssinger

文献索引：Nicolaou; Hepworth, David; King, N. Paul; Raymond; Finlay; Scarpelli, Rita; Manuela; Pereira; Bollbuck, Birgit; Bigot, Antony; Werschkun, Barbara; Winssinger, Nicolas Chemistry - A European Journal, 2000 , vol. 6, # 15 p. 2783 - 2800

全文：HTML全文

被引用次数: 65

摘要

Abstract The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B 10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones ...