The Formal Total Synthesis of FR252921–An Immunosuppressant

JS Yadav, S Sengupta

文献索引：Yadav; Sengupta, Sandip European Journal of Organic Chemistry, 2013 , # 2 p. 376 - 388

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被引用次数: 4

摘要

Abstract The formal total synthesis of FR252921 is described. The key steps include the preparation of three fragments starting from 1, 4-butanediol,(R)-malic acid, and prenol, respectively, followed by two consecutive peptide couplings of the three fragments. Other key steps involve an allene-type rearrangement or enyne isomerization to install the triene moiety, a Seebach methylation, a Julia olefination to construct the trisubstituted diene unit, ...