Iron–Copper Cooperative Catalysis in the Reactions of Alkyl Grignard Reagents: Exchange Reaction with Alkenes and Carbometalation of Alkynes

…, D Ikeda, S Masui, M Yoshida, T Hayashi

文献索引：Shirakawa, Eiji; Ikeda, Daiji; Masui, Seiji; Yoshida, Masatoshi; Hayashi, Tamio Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 272 - 279

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被引用次数: 63

摘要

Iron–copper cooperative catalysis is shown to be effective for an alkene–Grignard exchange reaction and alkylmagnesiation of alkynes. The Grignard exchange between terminal alkenes (RCH CH2) and cyclopentylmagnesium bromide was catalyzed by FeCl3 (2.5 mol%) and CuBr (5 mol%) in combination with PBu3 (10 mol%) to give RCH2CH2MgBr in high yields. 1-Alkyl Grignard reagents add to alkynes in the presence of a catalyst system ...