Synthesis of Azole Nucleoside 5′??Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases

…, TW Bruice, K Tucker, P Fagan, JL Brooks…

文献索引：Wang, Guangyi; Sakthivel, Kandasamy; Rajappan, Vasanthakumar; Bruice, Thomas W.; Tucker, Kathleen; Fagan, Patrick; Brooks, Jennifer L.; Hurd, Tiffany; Leeds, Janet M.; Cook, P. Dan Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 317 - 337

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被引用次数: 15

摘要

IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′??MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not assured, and usually is inefficient. In order to bypass cellular phosphorylation, a series of azole nucleoside 5′??MP mimics (P1Ms) based on ribavirin, EICAR and bredinin were ...