N-Substituted (2, 3-dihydro-1, 4-benzodioxin-2-yl) methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents
AM Birch, PA Bradley, JC Gill, F Kerrigan…
文献索引：Birch, Alan M.; Bradley, Paul A.; Gill, Julie C.; Kerrigan, Frank; Needham, Pat L. Journal of Medicinal Chemistry, 1999 , vol. 42, # 17 p. 3342 - 3355
A series of N-substituted 1-(2, 3-dihydro-1, 4-benzodioxin-2-yl) methylamine derivatives with D2 antagonist/5-HT1A partial agonist activity has been prepared as potential atypical antipsychotic agents. Optimization of in vitro receptor binding activity and in vivo activity in rodent models of psychosis has led to compound 24, which showed good affinities for human D2, D3, and 5-HT1A receptors but significantly less affinity for human α1 ...
