Identification of new triarylethylene oxyalkanoic acid analogues as bone selective estrogen mimetics

VN Rubin, PC Ruenitz, FD Boudinot, JL Boyd

文献索引：Rubin, Valeria N; Ruenitz, Peter C; Boudinot; Boyd, Jason L Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1579 - 1587

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被引用次数: 23

摘要

Previously, the estrogen receptor (ER) ligand 4-[1-(p-hydroxyphenyl)-2-phenylethyl] phenoxyacetic acid (5) was found to have differential bone loss suppressive effects in the ovariectomized (OVX) rat approaching those of selective ER modulators (SERMs) such as tamoxifen. In an effort to improve efficacy, analogues of this compound were prepared which incorporated features designed to reduce polarity/ionizability. Thus, the acetic acid side ...