(3 R)-N-(1-(tert-Butylcarbonylmethyl)-2, 3-dihydro-2-oxo-5-(2-pyridyl)-1 H-1, 4-benzodiazepin-3-yl)-N'-(3-(methylamino) phenyl) urea (YF476): A Potent and …

…, M Satoh, A Nishida, S Akuzawa, K Miyata

文献索引：Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341

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被引用次数: 79

摘要

A number of new 1, 4-benzodiazepin-2-one-based gastrin/CCK-B receptor antagonists related to the archetypal analogue L-365,260, and more closely to the recently reported compound YM022, have been synthesized and evaluated for biological activity. The compounds were screened for their ability to inhibit the binding of [125I] CCK-8 to gastrin/CCK-B receptors prepared from rat brains and that of [3H] L-364,718 to CCK-A ...