Automated process research. An example of accelerated optimization of the Friedel-crafts acylation reaction, a key step for the synthesis of anti-HIV (+)-calanolide A

…, EW Kirchhoff, DE Zembower, N Jimenez…

文献索引：Zhang, Jintao; Kirchhoff, Eric W.; Zembower, David E.; Jimenez, Nancy; Sen, Prabir; Xu, Ze-Qi; Flavin, Michael T. Organic Process Research and Development, 2000 , vol. 4, # 6 p. 577 - 580

全文：HTML全文

被引用次数: 15

摘要

An automated process research approach to reaction optimization was developed. Chemical process research can be greatly accelerated by coupling automated synthesis equipment with statistical design of experiments (DoE). With the use of an automated process approach, multiple experiments can be performed in parallel on an automated platform, and multiple parameters that may influence process performance can be ...