Novel pathway for the synthesis of arylpropionamide-derived selective androgen receptor modulator (SARM) metabolites of andarine and ostarine

…, G Forsdahl, G Gmeiner, VS Enev, P Gaertner

文献索引：Schragl, Katharina M.; Forsdahl, Guro; Gmeiner, Guenter; Enev, Valentin S.; Gaertner, Peter Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2239 - 2242

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被引用次数: 4

摘要

O-Dephenylandarine and O-dephenylostarine, two SARM metabolites relevant for doping control analysis, were synthesized in their endogenous (S)-forms as well as in terms of their racemates. The enantiopure (S)-metabolites were obtained after six steps in 20% and 23% overall yield, the slightly modified racemic route provided the compounds in 28% and 31% total yield, respectively.