Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H 1 receptors

RC Blakemore, CR Ganellin, M Garbarg, C Gros…

文献索引：Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al. European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100

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被引用次数: 19

摘要

Direct iodination of mepyramine and of hydroxy analogues of mepyramine and temelastine (SK&F 93944) furnishes derivatives which have lower receptor affinities than the parent compounds. In another approach, novel aminoalkyl derivatives of mepyramine are converted via the [ 125 I]Bolton—Hunter reagent into the corresponding 3-(4-hydroxy-5-[ 125 I]-iodophenyl)propionamides, each of which is separated chromatographically and its ...