Efficient Synthesis of Biologically Interesting 3, 4??Diaryl??Substituted Succinimides and Maleimides: Application of Iron??Catalyzed Carbonylations

…, KM Driller, R Jackstell, A Spannenberg…

文献索引：Prateeptongkum, Saisuree; Driller, Katrin Marie; Jackstell, Ralf; Spannenberg, Anke; Beller, Matthias Chemistry - A European Journal, 2010 , vol. 16, # 31 p. 9606 - 9615

全文：HTML全文

被引用次数: 30

摘要

Abstract A straightforward two-step synthesis of trans-3, 4-disubstituted succinimides through a palladium-catalyzed Sonogashira reaction and an iron-catalyzed double carbonylation is described. In situ oxidative dehydrogenation gave the corresponding 3, 4- diarylmaleimides. By starting from readily available aryl and heteroaryl halides, a variety of new analogues and derivatives of bioactive 3, 4-bisindolylmaleimides are obtained in ...