Highly stereoselective and completely regiospecific method for the dehydration of. beta.-hydroxy esters via. beta.-alanoxy enolates. Application to the synthesis of …
JA Katzenellenbogen, T Utawanit
文献索引：Katzenellenbogen,J.A.; Utawanit,T. Journal of the American Chemical Society, 1974 , vol. 96, p. 6153 - 6158
Abstract: The treatment of a/3-hydroxy ester with aluminum ethoxide or diethoxyaluminum chloride, followed by warming with added lithium diisopropylamide, produces the corresponding cu, P-unsaturated ester in moderate yield (44-56%). This process is completely regiospecific (no P, r isomers formed) and in suitably substituted cases is completely stereospecific, producing only the E olefin isomer. It is conceived that the ...
