Tetrahedron

Catalytic asymmetric oxidation of sulfide with titanium–mandelic acid complex: practical synthesis of (S)-3-[1-(2-methylphenyl) imidazol-2-ylsulfinyl] propan-1-ol, the …

…, N Fukuda, Y Muguruma, T Yamaguchi, J Minamikawa…

文献索引：Matsugi; Fukuda; Muguruma; Yamaguchi; Minamikawa; Otsuka Tetrahedron, 2001 , vol. 57, # 14 p. 2739 - 2744

全文：HTML全文

被引用次数: 48

摘要

An effective catalytic asymmetric oxidation of prochiral sulfide 1a to (S)-2a has been achieved by the use of chiral titanium–mandelic acid complex. The enantioselectivity was found to be not influenced by moisture, and moderate to high selectivity (76% ee) was obtained at room temperature (25° C). Thus a practical synthetic method for the platelet adhesion inhibitor, OPC-29030, was established utilising asymmetric oxidation of 1a.