The Journal of organic chemistry

Regioselective palladium-catalyzed formate reduction of N-heterocyclic allylic acetates

HY Cheng, CS Sun, DR Hou

文献索引：Cheng, Hsiu-Yi; Sun, Chong-Si; Hou, Duen-Ren Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2674 - 2677

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被引用次数: 17

摘要

The regioselective palladium-catalyzed formate reduction of allylic acetates in five-to eight- membered heterocycles is reported. Reduction of allylic acetates under mild conditions using allylpalladium chloride dimer, phosphines, and formic acid/triethylamine in DMF gives the exo-cyclic olefins in good regioselectivities and high yields. Synthetic application in preparing N-tosyl-3-oxo-piperidine is also reported.