One-Pot Synthesis of Internal Conjugated (Z)-Enynyltrimethylsilanes Possessing Aryl, Cycloalkenyl,(E)-or (Z)-Alk-1-enyl Moieties on the sp Carbon Atom via Two …
Abstract Described herein is an operationally simple and mild method for the stereospecific synthesis of internal conjugated (Z)-enynyltrimethylsilanes whose conjugation is extended away from the distal alkynyl carbon atom. This protocol involves two types of cross-coupling reaction, a Suzuki-type reaction and a sila-Sonogashira reaction, and the desired synthesis can be performed in a one-pot manner. Thus, the copper-mediated cross-coupling ...
