Tetrahedron: Asymmetry

Asymmetric dihydroxylation route to (R)-isoprenaline,(R)-norfluoxetine and (R)-fluoxetine

P Kumar, RK Upadhyay, RK Pandey

文献索引：Kumar, Pradeep; Upadhyay, Rajesh Kumar; Pandey, Rajesh Kumar Tetrahedron Asymmetry, 2004 , vol. 15, # 24 p. 3955 - 3959

全文：HTML全文

被引用次数: 42

摘要

Norfluoxetine 2 and fluoxetine 3 are among the most important pharmaceuticals for the treatment of psychiatric disorders (depression, anxiety, alcoholism) and also metabolic problems (obesity and bulimia). 5 In view of different pharmacological activities displayed by the individual enantiomers and differences in metabolic behaviour, the asymmetric synthesis of both enantiomers of fluoxetine and related compounds has received growing interest in recent years. Most of these ...