Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra-and cis-hexahydrophthalazinones

M Van der Mey, A Hatzelmann…

文献索引：Csende; Szabo Synthetic Communications, 1993 , vol. 23, # 21 p. 2957 - 2964

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被引用次数: 46

摘要

... Volume: Page: ... arthritis, could potentially be treated by the application of selective and potent PDE4 inhibitors, 20-23 because the ... The synthetic procedures used for the preparation of the 4-aryl-substituted hexahydrophthalazinones and some of the 4a,5,8,8a ...